Moreover, although the prevalence of diabetes is high, nearly half of the individuals living with diabetes are unaware of their disease status. Almost 10% of the world’s adult population (nearly 500 million individuals) live with diabetes, with the prevalence expected to increase to 700 million by 2045. Confounding factors, such as red blood cell counts can affect the association between Hb and HbA1c levels.ĭiabetes is one of the most prevalent diseases globally. Our findings revealed that Hb levels within the normal range were negatively associated with HbA1c levels among Chinese non-diabetes adults. However, this association did not remain significant when the regression model was minimally adjusted for age and sex (β =0.006, 95% CI: − 0.014, 0.024) this association became negative when the model was further adjusted for covariates whose effect estimates of HbA1c levels more than 10% (β = − 0.042, 95% CI: − 0.064, − 0.020). The association between Hb and HbA1c levels was positive in the unadjusted model (β =0.020, 95% CI: 0.008, 0.032). Subgroup analyses stratified by age and sex were also performed.
Multivariable linear models were applied to examine the association between Hb and HbA1c levels. Our analysis was based on the data of 1659 non-diabete adults 20–49 years of age. Therefore, our aim in this study was to evaluate the association between Hb levels within the normal range and HbA1c levels among Chinese non-diabetes adults using cross-sectional data from the China Health and Nutrition Survey 2009. However, the association between Hb and HbA1c remains to be fully elucidated in view of the controversial findings reported to date. Hemoglobin A1c (HbA1c) is the product of a non-enzymatic chemical reaction between hemoglobin (Hb) and glucose.
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